Do you provide MetID support?

Yes. MetID support includes metabolite identification, phase I and phase II metabolite characterization, HRMS profiling, and suspected metabolite confirmation.

ISO 17025–ACCREDITED LABORATORY ENVIRONMENT

Drug Categories Supported for DMPK and Bioanalytical Services

Q: Can you quantify both parent drugs and metabolites?

Yes. Services include parent-drug quantification, metabolite quantification, parent-metabolite ratio analysis, and multi-analyte panel development.

Explore analytical support by therapeutic area, drug class, parent compound, metabolite, pathway, or service need. This library connects drug-centered research questions with LC-MS/MS quantification, MetID, PK exposure profiling, biomarker readouts, and customized method development.

Parent Drug FirstDrug-Centered Index

Start from a parent compound or drug class, then connect to relevant metabolites and analytical needs.

Mechanism-AwarePathway & Biomarkers

Link drug exposure with pathway-associated readouts for mechanism and response interpretation.

Service-MatchedDMPK Workflows

Map study goals to quantification, MetID, PK support, DDI, or multi-analyte panel services.

Explore Drug Categories Discuss Your Compound

Library LogicDMPK Workflow

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Parent DrugRepresentative drug molecule or class anchor

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Metabolites & IntermediatesActive forms, degradation products, phase I/II metabolites

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PK / ExposurePlasma, tissue, urine, tumor, brain, bile, and cell matrices

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MetIDLC-MS/MS, HRMS profiling, suspected metabolite confirmation

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Pathway & BiomarkersMechanistic readouts and downstream functional indicators

How to Use This Library Research Dimensions Drug Categories Supported Core Service Capabilities Recommended Workflow Frequently Asked Questions

How to Use This Library

Move from Therapeutic Area to Analytical Strategy

This library category maps out our validated LC-MS/MS assay workflows across diverse therapeutic classes. Researchers can immediately review mature protocols tailored to their specific parent compound, target metabolites, and challenging biological matrices.

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Select a Therapeutic Category

Start with the disease or therapeutic area most relevant to your study, such as oncology, anti-infective, CNS, cardiovascular, endocrine, or natural product research.

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Identify Drug Classes or Parent Compounds

Narrow the scope to representative drug families, parent drugs, active metabolites, degradation products, or related pathway-associated analytes.

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Match Study Needs with Services

Connect your target analytes and matrices with quantification, MetID, parent-metabolite ratio analysis, DDI, PK support, or biomarker measurement.

Research Dimensions

What Each Drug Entry Can Help You Explore

Each reference entry delivers multi-dimensional pharmacokinetic and bioanalytical insights, evaluating target analytes from core parent drug clearance to downstream metabolite identification and biomarker pathways.

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Parent Drug

Use representative parent compounds as the starting point for drug-specific bioanalysis, PK support, and study planning.

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Metabolites & Intermediates

Track major metabolites, active forms, inactive products, degradation products, and pathway-relevant intermediates.

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PK / Exposure

Evaluate relevant matrices and exposure patterns across plasma, serum, urine, tissue, tumor, brain, bile, or cell samples.

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MetID

Support metabolite identification through targeted LC-MS/MS, HRMS profiling, phase I/II characterization, and structural confirmation.

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Pathway & Biomarkers

Connect drug exposure with mechanism-related readouts, including inflammatory, immune, hormone, metabolic, neural, and tumor markers.

Drug Categories Supported

Browse by Therapeutic Area

Explore our tailor-made DMPK and bioanalytical screening strategies sorted by therapeutic area, addressing unique drug clearance mechanisms, tissue distribution profiles, and disease-specific biomarker readouts.

9 categories shown

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Infection / Exposure

Anti-Infective Drugs

Support for antibiotics, antivirals, and antifungal agents, with emphasis on parent-drug exposure, renal excretion, tissue penetration, stability, and infection-associated response markers.

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Tumor / Pathway

Oncology Drugs

Analytical support for cytotoxic agents, targeted therapies, biologics, ADCs, and PROTACs, focusing on tumor exposure, active metabolites, pathway inhibition, and PK/PD-linked biomarkers.

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Plasma / DDI

Cardiovascular Drugs

Bioanalytical support for cardiovascular drug classes, including plasma exposure analysis, active metabolite quantification, CYP/transporter-related DDI assessment, and functional cardiovascular readouts.

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Brain / Neurotransmitters

CNS Drugs

Support for CNS-active compounds requiring plasma–brain exposure assessment, active metabolite analysis, neurotransmitter-related biomarkers, and low-level bioanalytical method development.

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Pain / Metabolites

Analgesics & Controlled Drugs

Services for NSAIDs, opioids, anesthetics, and controlled drug classes, including parent–metabolite ratio analysis, glucuronide metabolite quantification, and pain or inflammation-associated readouts.

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Hormone / Metabolism

Endocrine & Metabolic Drugs

Support for antidiabetic agents, thyroid-related drugs, steroid hormones, and metabolic disease compounds, linking drug exposure with hormone-axis and metabolic biomarker readouts.

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Narrow Exposure

Immunosuppressive Drugs

High-sensitivity analytical support for immunosuppressive agents with narrow exposure ranges, CYP3A/P-gp interactions, metabolite monitoring needs, and immune pathway-related biomarkers.

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Liver / Bile

Gastrointestinal & Hepatobiliary Drugs

Support for gastrointestinal and hepatobiliary drug studies involving hepatic metabolism, bile-related matrices, acid-suppression agents, bile acid-related analytes, and liver-associated biomarkers.

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Multi-Component

Natural Products

Analytical support for natural product-derived compounds, complex mixtures, phase II conjugates, gut microbiota-related metabolites, and low-abundance bioactive components.

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Core Service Capabilities

Services Connected to Drug-Centered Research Questions

Across therapeutic categories, Creative Proteomics can support quantitative, mechanistic, and method-development needs using LC-MS/MS, HRMS, targeted metabolomics, and matrix-aware bioanalytical workflows.

Quantitative Bioanalysis

Parent-drug and metabolite quantification is often the primary entry point for DMPK studies. Assays can be designed around target analytes, expected concentration range, and matrix complexity.

Metabolism & MetID

Support for metabolite identification, phase I/phase II characterization, parent-metabolite ratio analysis, and reactive metabolite screening.

Explore metabolism services →

DDI & Transporters

CYP inhibition, induction, time-dependent inhibition, and transporter interaction bioanalysis for mechanism-linked exposure questions.

Explore DDI services →

Multi-Analyte Panels

Therapeutic class panels, preclinical PK panels, parent-metabolite panels, and high-sensitivity multiplex quantification.

Explore panel development →

Method Development

Custom LC-MS/MS methods, HPLC-UV development, matrix-specific sample preparation, and full, partial, or cross-validation.

Explore method development →

Recommended Workflow

From Drug Selection to Analytical Output

Whether the project starts from a known drug, investigational compound, metabolite, degradation product, or pathway biomarker, the workflow can be aligned with the target analyte and study objective.

Submit Drug Information

Share the parent drug, compound class, metabolite, pathway, or biomarker of interest.

Define Analytes & Matrices

Clarify whether the study involves plasma, serum, urine, tissue, tumor, brain, bile, cell lysate, or another matrix.

Select Analytical Strategy

Choose targeted LC-MS/MS, HRMS profiling, MetID, multi-analyte panels, or custom method development.

Develop or Validate Method

Optimize extraction, chromatography, mass transitions, calibration, LLOQ, precision, and matrix effects as needed.

Deliver Research Data

Receive quantitative outputs, MetID interpretation, method notes, QC summaries, and project-specific reporting.

FAQ

Frequently Asked Questions

Yes. Creative Proteomics can develop customized analytical methods for proprietary compounds, investigational drugs, metabolites, degradation products, or structurally related analytes.

Yes. We support parent-drug quantification, metabolite quantification, parent-metabolite ratio analysis, and multi-analyte panel development.

Common matrices include plasma, serum, urine, tissue homogenates, tumor samples, brain tissue, bile, cell lysates, and other biological matrices depending on study requirements.

Yes. We support metabolite identification, phase I/phase II metabolite characterization, HRMS profiling, and suspected metabolite confirmation.

Yes. Drug exposure data can be integrated with pathway-associated biomarkers such as inflammatory mediators, neurotransmitters, immune markers, hormone-axis readouts, metabolic indicators, and tumor pathway biomarkers.

Drug Categories Supported for DMPK and Bioanalytical Services

Move from Therapeutic Area to Analytical Strategy

Select a Therapeutic Category

Identify Drug Classes or Parent Compounds

Match Study Needs with Services

What Each Drug Entry Can Help You Explore

Parent Drug

Metabolites & Intermediates

PK / Exposure

MetID

Pathway & Biomarkers

Browse by Therapeutic Area

Anti-Infective Drugs

Oncology Drugs

Cardiovascular Drugs

CNS Drugs

Analgesics & Controlled Drugs

Endocrine & Metabolic Drugs

Immunosuppressive Drugs

Gastrointestinal & Hepatobiliary Drugs

Natural Products

Services Connected to Drug-Centered Research Questions

Quantitative Bioanalysis

Metabolism & MetID

DDI & Transporters

Multi-Analyte Panels

Method Development

From Drug Selection to Analytical Output

Submit Drug Information

Define Analytes & Matrices

Select Analytical Strategy

Develop or Validate Method

Deliver Research Data

Frequently Asked Questions

Ready to Quantify Your Lead Compound or Metabolite?